Biomedicine ? General
Part 1
The aim of the present study was to evaluate the relation between the incidence of coronary heart disease (CHD) and the reduction in total antioxidant capacity (TAC) that has not been completely explained yet. We have provided the TAC assessment of blood serum in two groups; one consists of 163 males aged between 34.8?77.0 years with CHD and second group of size 163 members age-matched peer individuals without CHD. In order to assess TAC were applied two spectrophotometries; ferric reducing ability of serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyle (TAC-DPPH) tests. The results of multivariate analysis in first group with CHD indicate that uric acid (UA), triglycerides, and systolic blood pressure contribute independently to the TAC-FRAS variance. TAC-DPPH was positively predicted by UA concentration, but negatively by current smoking and glucose levels. The results in males without CHD show that UA was the only independent determinant of both spectrophotometries – TAC-FRAS and TAC-DPPH. Presence of CHD was not independent predictor of TAC that was observed between-group differences with higher TAC in CHD patients. Occurrence of CHD related to TAC disappeared after adjustment for other confounders. We conclude that UA is the main determinant of TAC of blood serum in males. TAC is rel

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